Strain relaxation of fibroblasts in the marginal periodontium is the common trigger for alveolar bone resorption: a novel hypothesis.
J Periodontol
; 73(10): 1210-5, 2002 Oct.
Article
en En
| MEDLINE
| ID: mdl-12416781
ABSTRACT
In summary, the present commentary proposes a hypothesis that alveolar bone remodeling and bone loss in periodontitis, periodontal surgery, and in orthodontic tooth movement is triggered by a common "strain relaxation" signaling pathway of gingival and periodontal fibroblasts. The abrupt splitting, degradation, or relaxation of collagen fibers in the marginal periodontium produces a "strain relaxation" signal in the local fibroblasts which reside on these fibers, activating an ECM-integrin-cytoskeleton pathway. A cascade of cellular reactions which lead to osteoclastic bone resorption starting on the inner aspect (periodontal) of the alveolar bone then persists. A novel therapeutic approach is suggested here by using locally delivered drugs intervening in the cell contractile apparatus.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Periodontitis
/
Periodoncio
/
Pérdida de Hueso Alveolar
/
Fibroblastos
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Periodontol
Año:
2002
Tipo del documento:
Article
País de afiliación:
Israel