Genetics of sensory mechanotransduction.
Annu Rev Genet
; 36: 411-53, 2002.
Article
en En
| MEDLINE
| ID: mdl-12429699
ABSTRACT
The molecular mechanisms for the transduction of light and chemical signals in animals are fairly well understood. In contrast, the processes by which the senses of touch, balance, hearing, and proprioception are transduced are still largely unknown. Biochemical approaches to identify transduction components are difficult to use with mechanosensory systems, but genetic approaches are proving more successful. Genetic research in several organisms has demonstrated the importance of cytoskeletal, extracellular, and membrane components for sensory mechanotransduction. In particular, researchers have identified channel proteins in the DEG/ENaC and TRP families that are necessary for signaling in a variety of mechanosensory cells. Proof that these proteins are components of the transduction channel, however, is incomplete.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Mecanotransducción Celular
Límite:
Animals
Idioma:
En
Revista:
Annu Rev Genet
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos