In vitro autoreactivity against skin and synovial cells in patients with juvenile idiopathic and rheumatoid arthritis.
Pathobiology
; 70(2): 76-82, 2002.
Article
en En
| MEDLINE
| ID: mdl-12476032
ABSTRACT
In the present study we compared specific lysis of various autologous target cells in patients with juvenile idiopathic arthritis JIA; n = 8) or rheumatoid arthritis RA; n = 17) with those of healthy controls (n = 15). (51)Cr-release cytotoxic assay with autologous peripheral blood mononuclear cells as effector cells was used. When compared with controls, effector cells of patients with JIA or RA were found to lyse significantly autologous synovial cells (p < 0.0005) and epidermal keratinocytes (p < 0.0005), however, no difference was found for autologous dermal fibroblasts.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_immune_disorders
/
6_musculoskeletal_diseases_rheumatic_disorders
Asunto principal:
Artritis Juvenil
/
Membrana Sinovial
/
Autoinmunidad
/
Queratinocitos
/
Fibroblastos
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Pathobiology
Asunto de la revista:
PATOLOGIA
Año:
2002
Tipo del documento:
Article
País de afiliación:
República Checa