Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient.
Transpl Infect Dis
; 4(4): 201-6, 2002 Dec.
Article
en En
| MEDLINE
| ID: mdl-12535263
ABSTRACT
A 20-year-old patient, who received a bone marrow transplant in order to treat metachromatic leukodystrophy (MLD), succumbed to cytomegalovirus (CMV) encephalitis. After CMV viremia developed, the patient received ganciclovir, but he was switched to foscarnet when ganciclovir resistance was suspected. Foscarnet was discontinued because of concern about its potential central nervous system toxicity. Autopsy samples of brain and cerebrospinal fluid contained CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. No foscarnet resistance mutations were found.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Ganciclovir
/
Trasplante de Médula Ósea
/
Infecciones por Citomegalovirus
/
Encefalitis Viral
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Transpl Infect Dis
Asunto de la revista:
TRANSPLANTE
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos