A new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage.
J Am Chem Soc
; 125(4): 882-3, 2003 Jan 29.
Article
en En
| MEDLINE
| ID: mdl-12537482
ABSTRACT
A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
/
2,2'-Dipiridil
/
4-Aminopiridina
/
Bloqueadores de los Canales de Potasio
Límite:
Animals
Idioma:
En
Revista:
J Am Chem Soc
Año:
2003
Tipo del documento:
Article
País de afiliación:
Argentina