Imidazopyrimidines, potent inhibitors of p38 MAP kinase.
Bioorg Med Chem Lett
; 13(3): 347-50, 2003 Feb 10.
Article
en En
| MEDLINE
| ID: mdl-12565927
ABSTRACT
The MAP kinase p38 is implicated in the release of the pro-inflammatory cytokines TNF-alpha and IL-1 beta. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A novel series of imidazopyrimidines have been discovered that potently inhibit p38 and suppress the production of TNF-alpha in vivo.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Quinasas Activadas por Mitógenos
/
Inhibidores Enzimáticos
/
Imidazoles
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos