Studies on correlation of antimutagenic and antiproliferative activities of Juglans regia L.
J Environ Pathol Toxicol Oncol
; 22(1): 59-67, 2003.
Article
en En
| MEDLINE
| ID: mdl-12678406
ABSTRACT
We investigated the effect of water and acetone extract of Juglans regia L. to evaluate its antimutagenic and antiproliferative activities. The antimutagenic study using TA98 and TA100 tester strains of Salmonella revealed the water and acetone extracts to be more effective than the benzene and chloroform extracts in inhibiting the revertants induced by 2-aminoflourene (2AF) in TA100 tester strains. The most effective extracts in the Ames assay were further evaluated using the Lucifer luciferase assay and in time course studies for antiproliferative activities using the Hoechst staining to observe apoptotic cell deaths. The acetone extract showed a correlation of antimutagenic activities in the Ames assay with its antiproliferative effect in different cell lines, while the water extract exerted its effect distinctly in each cell line. Further studies are still needed to evaluate the cytotoxicity in experiments carried out in vivo.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
División Celular
/
Estructuras de las Plantas
/
Preparaciones de Plantas
/
Juglans
/
Fitoterapia
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
J Environ Pathol Toxicol Oncol
Asunto de la revista:
NEOPLASIAS
/
PATOLOGIA
/
SAUDE AMBIENTAL
/
TOXICOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
India