Effect of levetiracetam in refractory childhood epilepsy syndromes.
Eur J Paediatr Neurol
; 7(3): 123-8, 2003.
Article
en En
| MEDLINE
| ID: mdl-12788038
ABSTRACT
In this open-label add-on study of levetiracetam in refractory childhood epilepsy syndromes, we studied the effect of a rapid introduction of levetiracetam on the total seizure frequency in 21 children, known to have partial and generalized seizures. Starting dosage was 10 mg/kg/day, increased every 4th day by 10 mg/kg up to a maximum of 60 mg/kg/day, depending on efficacy and tolerability. In this highly refractory population, 47% showed a seizure frequency reduction of more than 50%. Levetiracetam was effective both in partial and generalized seizures, with a significant effect on myoclonic seizures. Only mild side-effects were observed in four of 21 children, at a dosage of more than 40 mg/kg/day.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piracetam
/
Epilepsias Parciales
/
Epilepsia Generalizada
/
Anticonvulsivantes
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Eur J Paediatr Neurol
Asunto de la revista:
NEUROLOGIA
/
PEDIATRIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Bélgica