Measurement of diffusion coefficients of parabens and steroids in water and 1-octanol.
Chem Pharm Bull (Tokyo)
; 51(6): 734-6, 2003 Jun.
Article
en En
| MEDLINE
| ID: mdl-12808257
ABSTRACT
Diffusion coefficients (D) of parabens and steroids in water and 1-octanol were determined by using the chromatographic broadening method at 37 degrees C, and the relationships between the D values and the physicochemical properties of the drugs were discussed. The D values in 1-octanol were lower than those in water because of the higher viscosity of 1-octanol. The D values depend on not only the molecular weight (MW), but also the lipophilicity of the drugs in water and on the ability for hydrogen-bonding in 1-octanol. When the lipophilic index (LI), calculated from the retention time using in a reverse-phase column, was used as a parameter of drug lipophilicity, the following equation was obtained for D in water (D(w)); log D(w)=-0.215.log MW-0.077.log LI-4.367. When the hydrogen bond index (HI), the logarithm of the ratio of the partition coefficient of the drugs in 1-octanol and cyclohexane, was used as an index of hydrogen-bonding, the following equation was obtained for D in 1-octanol (D(o)); log D(o)=-0.690.log MW-0.074.log HI-4.085.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Parabenos
/
Esteroides
/
Agua
/
1-Octanol
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Año:
2003
Tipo del documento:
Article
País de afiliación:
Japón