Is there an association between Helicobacter pylori cytotoxin Cag A seropositivity and risk for gastric cancer?
Ann Ital Chir
; 73(6): 571-6; discussion 577-8, 2002.
Article
en En
| MEDLINE
| ID: mdl-12820580
ABSTRACT
BACKGROUND:
Since discovered in 1990, Cag A, a protein expressed by specific strains of Helicobacter pylori, was thought able to explain why only a few Helicobacter infected patients develop peptic diseases and gastric cancer. However, clinical trials provide discordant results. MATERIALS ANDMETHODS:
In this study we evaluate Helicobacter pylori and Cag A seropositivity in 35 cancer affected patients, in 36 gastritis affected patients and in 40 healthy blood donors by means of two commercially available fluorescence enzyme-immunoessay (ELISA).RESULTS:
Odds ratios determination strongly suggests that Cag A bearer Helicobacter strains play a pathogenetic role in gastric diseases (OR 4.23, 95% CI 3.22-5.24 for cancer versus healthy volunteers, OR 3.2, 95% CI 2.19-4.21 for gastritis versus asymptomatic patients), but is unable to demonstrate a direct carcinogenic activity (cancer-gastritis difference is not significant OR 1.32, 95% CI 0.39-1.25).CONCLUSIONS:
Cag A seropositivity can be considered a risk factor for peptic disease, and only indirectly for gastric carcinoma. The paper also discuss some sampling, laboratory and statistical bias that can explain a wide eterogenity of the results reported in the literature.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
/
Proteínas Bacterianas
/
Carcinoma
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Citotoxinas
/
Gastritis
/
Antígenos Bacterianos
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ann Ital Chir
Año:
2002
Tipo del documento:
Article
País de afiliación:
Italia