Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage.
Eur J Immunol
; 33(7): 1968-77, 2003 Jul.
Article
en En
| MEDLINE
| ID: mdl-12884863
ABSTRACT
The pre-T cell receptor (pre-TCR) and IL-7 receptor (IL-7R) are critical mediators of survival, proliferation and differentiation in immature thymocytes. Here we show that pre-TCR signaling directly maintains IL-7Ralpha expression as developing thymocytes undergo beta-selection. Inhibition of IL-7/IL-7R signaling in (CD44-CD25-) DN4 cells results in decreased generation of double-positive thymocytes due to increased death of rapidly proliferating beta-selected cells. Thus, we identify a mechanism by which pre-TCR signaling controls the selective survival of TCRbeta+ thymocytes, and define a further stage of T cell differentiation in which signaling from a TCR regulates the ability of that cell to respond to cytokine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Timo
/
Regulación de la Expresión Génica
/
Complejo CD3
/
Receptores de Interleucina-7
Límite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Reino Unido