Evaluation of stability of cefuroxime axetil in solid state.
J Pharm Biomed Anal
; 32(6): 1181-7, 2003 Aug 21.
Article
en En
| MEDLINE
| ID: mdl-12907262
ABSTRACT
The effect of temperature and relative atmospheric humidity on the stability of the crystalline form of cefuroxime axetil (CFA) in solid state was investigated. CFA is a mixture of diastereomers A and B. Changes in the concentration of the two diastereomers (A and B) of CFA were recorded by means of HPLC with UV detection. The degradation of diastereomers of CFA occurring at 0% relative humidity (RH) of the ambient air is a reversible first order reaction, while that occurring in humid air (RH>50%) is an autocatalytic first order reaction relative to substrate concentration. Although it has been found, that diastereomer B is the more stable isomer, humidity has a stronger effect on this very diastereomer.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cefuroxima
/
Antibacterianos
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Idioma:
En
Revista:
J Pharm Biomed Anal
Año:
2003
Tipo del documento:
Article
País de afiliación:
Polonia