Differential in vitro inhibition of feline enteric coronavirus and feline infectious peritonitis virus by actinomycin D.
J Gen Virol
; 73 ( Pt 12): 3285-8, 1992 Dec.
Article
en En
| MEDLINE
| ID: mdl-1335030
ABSTRACT
The growth of feline enteric coronavirus strain 79-1683 in whole feline embryo cells was inhibited by the presence of 1 microgram/ml of actinomycin D in the culture fluid. No virus-specific mRNAs could be detected in such cultures and yields of infectious virus were depressed by > 99%. By contrast, the antigenically related feline infectious peritonitis virus strain 79-1146 was unaffected by the presence of actinomycin D, indicating a fundamental difference between the two feline coronavirus strains in their requirements for host-encoded function(s).
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_zoonosis
Asunto principal:
Replicación Viral
/
Coronavirus Felino
/
Coronaviridae
/
Dactinomicina
Límite:
Animals
Idioma:
En
Revista:
J Gen Virol
Año:
1992
Tipo del documento:
Article
País de afiliación:
Reino Unido