Haemodynamic effects of different doses of dopexamine hydrochloride in low cardiac output states following cardiac surgery.
Eur Heart J
; 13(9): 1271-6, 1992 Sep.
Article
en En
| MEDLINE
| ID: mdl-1356772
ABSTRACT
We studied the haemodynamic effects of dopexamine hydrochloride, a beta 2-adrenergic agonist with dopaminergic (DA1) activity, in 20 patients with low cardiac output following surgery for coronary artery bypass grafting and/or valve replacement or repair. Following titration of four doses (1, 2, 4 and 6 micrograms.kg-1.min-1), the dose producing the optimal response was infused for up to 48 h (five patients). During the infusion, significant increases in cardiac index and stroke volume were accompanied by significant decreases in systemic vascular resistance. Heart rate increased significantly up to 6 h and thereafter returned to control levels. Mean blood pressure was reduced but did not fall below 60 mmHg. However, in five patients treated for 48 h mean blood pressure had returned to control levels. Unwanted effects (tachycardia and hypotension) were seen chiefly at higher doses, leading us to conclude that infusion rates of 4 micrograms.kg-1.min-1 or less will be useful in the treatment of low cardiac output following cardiac surgery.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complicaciones Posoperatorias
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Prótesis Valvulares Cardíacas
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Gasto Cardíaco Bajo
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Dopamina
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Puente de Arteria Coronaria
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Agonistas Adrenérgicos
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Insuficiencia Cardíaca
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Hemodinámica
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur Heart J
Año:
1992
Tipo del documento:
Article