Effect of enterovirus infection on susceptibility of HeLa cells to Shigella flexneri invasivity.
Acta Virol
; 36(5): 443-9, 1992 Oct.
Article
en En
| MEDLINE
| ID: mdl-1364020
ABSTRACT
Invasiveness of Shigella flexneri M90T in HeLa cells was significantly increased when cells were preinfected with poliovirus 1, coxsackievirus B3 and echovirus 6. This effect was dependent on the dose of virus used, evident at early stages of viral infection and lasted hours before the appearance of a cytopathic effect. An increase of bacterial invasion ability was also noticed when HeLa cells were incubated with UV-inactivated enteroviruses. This enhancing effect obtained with both viable and UV-inactivated enteroviruses was not observed when in coinfection experiments HN555, a mutant of S. flexneri M90T which lacked invasive properties, was used. The data presented here suggest that the early steps of enterovirus infection induce some alterations of HeLa cells which are responsible for the enhancing of the invasiveness of S. flexneri M90T, but not sufficient to promote internalization of a non-invasive strain.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Shigella flexneri
/
Células HeLa
/
Enterovirus Humano B
/
Poliovirus
/
Echovirus 6 Humano
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Virol
Año:
1992
Tipo del documento:
Article
País de afiliación:
Italia