Antibodies to choroid plexus in senile dementia of Alzheimer's type.
J Clin Pathol
; 45(9): 781-3, 1992 Sep.
Article
en En
| MEDLINE
| ID: mdl-1401207
ABSTRACT
AIMS:
To investigate whether autoantibodies to choroid plexus are present in human senile dementia.METHODS:
Serum samples from 40 elderly people presenting with characteristic, diagnostic criteria of senile dementia of Alzheimer's type and 20 age matched healthy controls were tested by indirect immunofluorescence for the presence of autoantibodies to choroid plexuses, using frozen sections of rat or human fetal brain tissue.RESULTS:
Significant labelling of choroid plexus basement membrane was observed in 17 of the 40 samples from patients with senile dementia; in the control series one sample of rat but not human plexus labelled positively (p < 0.01).CONCLUSIONS:
The antibodies identified in this series of patients with Alzheimer's disease suggest that autoimmune mechanisms might be responsible for some of the changes in cerebrospinal fluid production described in this disorder.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Plexo Coroideo
/
Enfermedad de Alzheimer
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Aged80
/
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Pathol
Año:
1992
Tipo del documento:
Article
País de afiliación:
Francia