Salmeterol versus sodium cromoglycate for the protection of exercise induced asthma in children--a randomised cross-over study.
Eur J Med Res
; 8(9): 428-34, 2003 Sep 29.
Article
en En
| MEDLINE
| ID: mdl-14555299
ABSTRACT
OBJECTIVE:
Physical activity is an important and frequent trigger of airways obstruction in asthmatic children. We aimed to compare the efficacies of 50 microg salmeterol twice daily and 2 mg SCG four times daily with respect to protection from exercise induced bronchoconstriction (EIB).METHODS:
Twenty seven children and adolescents aged 4 to 16 years with mild or moderate exercise induced asthma (FEV1 70% to 90% predicted) were admitted to the study. Exercise challenge was performed on a treadmill using a predefined protocol in order to produce 10 minutes of exercise at near-maximum targets. The trial had a randomised, cross-over design comprising a 3-day run-in period and two 7-day treatment periods, separated by a one-week washout period.RESULTS:
The mean protective efficacy of salmeterol was larger than that of SCG. A difference between treatments of 39.7% (95% CI, - 0,8 to 68.9%) in favour of salmeterol was calculated using a Hodges-Lehmann-estimate. The maximum post-challenge fall in FEV subset 1 was significantly lower (p<0.001) after salmeterol than after SCG (- 5.6 +/- 6.4% vs. -12.1 +/- 9.3%, respectively). In addition, salmeterol improved base-line lung function to a greater degree than SCG. FEV1 increased by 0.4 l/sec after salmeterol, whereas no improvement was observed after SCG.CONCLUSIONS:
A one-week treatment with salmeterol 50 microg b.i.d in asthmatic children and adolescents provided better protection against EIB and improved baseline lung function as compared to SCG four times daily.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Asma Inducida por Ejercicio
/
Broncodilatadores
/
Cromolin Sódico
/
Antiasmáticos
/
Albuterol
Tipo de estudio:
Clinical_trials
/
Guideline
Límite:
Adolescent
/
Child
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Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Med Res
Asunto de la revista:
MEDICINA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Alemania