Motor neuron columnar fate imposed by sequential phases of Hox-c activity.
Nature
; 425(6961): 926-33, 2003 Oct 30.
Article
en En
| MEDLINE
| ID: mdl-14586461
ABSTRACT
The organization of neurons into columns is a prominent feature of central nervous system structure and function. In many regions of the central nervous system the grouping of neurons into columns links cell-body position to axonal trajectory, thus contributing to the establishment of topographic neural maps. This link is prominent in the developing spinal cord, where columnar sets of motor neurons innervate distinct targets in the periphery. We show here that sequential phases of Hox-c protein expression and activity control the columnar differentiation of spinal motor neurons. Hox expression in neural progenitors is established by graded fibroblast growth factor signalling and translated into a distinct motor neuron Hox pattern. Motor neuron columnar fate then emerges through cell autonomous repressor and activator functions of Hox proteins. Hox proteins also direct the expression of genes that establish motor topographic projections, thus implicating Hox proteins as critical determinants of spinal motor neuron identity and organization.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Médula Espinal
/
Diferenciación Celular
/
Proteínas de Homeodominio
/
Regulación del Desarrollo de la Expresión Génica
/
Neuronas Motoras
Límite:
Animals
Idioma:
En
Revista:
Nature
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos