The synthesis and antibacterial activity of 1,3,4-thiadiazole phenyl oxazolidinone analogues.
Bioorg Med Chem Lett
; 13(23): 4193-6, 2003 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-14622999
ABSTRACT
Replacement of the morpholine C-ring of linezolid 1 with a 1,3,4-thiadiazolyl ring leads to oxazolidinone analogues 5 having potent antibacterial activity against both gram-positive and gram-negative organisms. Conversion of the C5 acetamide group to a thioacetamide further increases the potency of these compounds.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenoles
/
Tiadiazoles
/
Oxazolidinonas
/
Bacterias Grampositivas
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos