Theoretical study on the excited states of psoralen compounds bonded to a thymine residue.
J Comput Chem
; 25(2): 179-88, 2004 Jan 30.
Article
en En
| MEDLINE
| ID: mdl-14648617
ABSTRACT
Time-dependent density functional theory calculations have been performed for the excited states of psoralen, 5-methoxypsoralen, and 8-methoxypsoralen in systems and furan and pyrone monoadducts bonded to a thymine residue. The theoretical assignments to ultraviolet (UV) absorption spectra of isolated systems have been performed. The present calculations have clarified that the excitation energies of the first singlet excited (S1) state of monoadducts are blue-shifted compared with the isolated systems. It is shown that, in particular, the S1 excitation energy of the pyrone monoadduct is significantly blue-shifted and, therefore, the pyrone monoadduct is not excited by UV-A light (300-400 nm), which is used in the photochemotherapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Furocumarinas
/
Timina
Idioma:
En
Revista:
J Comput Chem
Asunto de la revista:
QUIMICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón