[The evaluation of the mutagenic activity of pertussis vaccinal preparations]. / Otsenka mutagennoi aktivnosti kokliushnykh vaktsinal'nykh preparatov.
Zh Mikrobiol Epidemiol Immunobiol
; (7-8): 42-5, 1992.
Article
en Ru
| MEDLINE
| ID: mdl-1466172
ABSTRACT
Two vaccine preparations obtained from Bordetella pertussis, whole-cell vaccine constituting one of the components of adsorbed DPT vaccine and acellular vaccine, were tested for mutagenicity. The doses of the preparations covered the range 1-100 ED50. Ames' test and the metaphase analysis of marrow cells of C57BL/6J mice were used. The acellular preparation was also tested on thymectomized mice, taking into consideration chromosomal aberrations in marrow metaphases. Whole-cell and acellular pertussis vaccines did not induce mutations in Salmonella typhimurium and chromosomal aberrations in mouse marrow cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Vacuna contra la Tos Ferina
/
Mutagénesis
Límite:
Animals
Idioma:
Ru
Revista:
Zh Mikrobiol Epidemiol Immunobiol
Año:
1992
Tipo del documento:
Article