Camptothecin-induced apoptosis in non-small cell lung cancer is independent of cyclooxygenase expression.
Apoptosis
; 8(6): 639-47, 2003 Dec.
Article
en En
| MEDLINE
| ID: mdl-14739609
ABSTRACT
Recent observations show a positive correlation between the expression of cyclooxygenase (COX), especially COX-2), and cancer development. Here we tested the hypothesis that expression of COX-2 could influence apoptosis in lung cancer cell lines. To address this question, we determined the effects of camptothecin-induced apoptosis on three lung cancer cell lines which over express COX-1 (CORL23), COX-2 (MOR-P) and neither isoform (H-460), and determine if these effects were prostaglandin mediated. We also compared the effects of non-selective and isoenzyme selective COX-2 inhibitors on camptothecin-induced apoptosis in these three cell lines. Camptothecin induced apoptosis in all three cell lines independently of COX-1 or COX-2 expression. Indomethacin, a non-selective COX inhibitor and NS398, a selective COX-2 inhibitor had no effect on camptothecin-induced apoptosis at concentrations that abolished prostaglandin production. In conclusion, these finding suggest that the COX pathway is not involved in camptothecin-induced apoptosis of non-small cell lung cancer cell lines.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Camptotecina
/
Prostaglandina-Endoperóxido Sintasas
/
Apoptosis
/
Carcinoma de Pulmón de Células no Pequeñas
/
Neoplasias Pulmonares
/
Antineoplásicos Fitogénicos
Idioma:
En
Revista:
Apoptosis
Año:
2003
Tipo del documento:
Article
País de afiliación:
España