Reperfusion arrhythmias after chronic regional denervation of the ischaemic myocardium in pigs.
Cardiovasc Res
; 26(10): 962-7, 1992 Oct.
Article
en En
| MEDLINE
| ID: mdl-1486589
ABSTRACT
OBJECTIVE:
The aim was to assess the effects of chronic regional denervation of the ischaemic myocardium on reperfusion arrhythmias in a model with sparse coronary collateral circulation.METHODS:
Baseline ventricular refractoriness and epicardial activation times were measured together with reperfusion arrhythmias after 15 min (I-15') or 30 min (I-30') of left anterior descending coronary artery occlusion in 38 barbiturate anaesthetised open chest pigs. Twenty pigs (11 in I-15' and nine in I-30') had a chronic (two week) denervation of the left anteroseptal region, whereas 18 pigs (10 in I-15' and eight in I-30') were sham operated (non-denervated) controls. Denervation was induced by pericoronary application of phenol and verified by absence of adrenergic histofluorescence.RESULTS:
As compared with controls, denervated pigs showed (1) longer activation times 20.3 (SD 5.2) ms v 16.5 (4.6) ms, p < 0.001; (2) slightly longer refractory periods 348(28) ms v 334(27) ms; (3) a tendency to lower postreperfusion ectopic activity ectopic beats divided by time free of ventricular tachycardia 0.13(0.19) v 0.34(0.40) in I-15', and 0.21(0.24) v 0.39(0.44) in I-30'; (4) slower ventricular tachycardia in I-30' 140(29) beats.min-1 v 185(29) beats.min-1, p < 0.009; and (5) comparable incidence of postreperfusion ventricular fibrillation 4/11 pigs v 2/10 in I-15', and 5/9 v 4/8 in I-30'.CONCLUSIONS:
Selective chronic denervation of the ischaemic myocardium was unable to protect against malignant reperfusion arrhythmias in hearts with human-like coronary collaterals. This was confirmed at two ischaemic periods known to produce progressive catecholamine accumulation and increased adrenoceptor density in the ischaemic myocardium.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arritmias Cardíacas
/
Simpatectomía
/
Daño por Reperfusión Miocárdica
/
Isquemia Miocárdica
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Cardiovasc Res
Año:
1992
Tipo del documento:
Article
País de afiliación:
España