Lipid transfer protein transports compounds from lipid nanoparticles to plasma lipoproteins.
Int J Pharm
; 275(1-2): 239-48, 2004 May 04.
Article
en En
| MEDLINE
| ID: mdl-15081154
ABSTRACT
Nanometer-sized lipid emulsion particles with a diameter of 25-50 nm, called Lipid Nano-Sphere (LNS), are expected as a promising drug carrier to show prolonged plasma half-life of an incorporating drug. In terms of successful drug delivery using LNS, a drug should be incorporated into the lipid particles and remain within the particle, not only in the formulation in vitro but also after administration into the systemic blood circulation. In this study, we showed that phospholipids and some water-insoluble molecules also moved from lipid particles to plasma lipoproteins or albumin in serum and plasma half-lives of these compounds did not reflect that of the drug carriers. It was suggested that phospholipid or its derivative were transferred from LNS particles to plasma lipoproteins by lipid transfer proteins (LTP) in the circulation. These phenomena leaded to unsuccessful delivery of the drug with lipid-particulate drug carriers. On the other hand, lipophilic derivatives with cholesterol pro-moiety tested in this study were not released from LNS particles and showed prolonged plasma half-lives. Lipophilicity is known to be an important parameter for incorporating drugs into lipid particles but substrate specificity for LTP seems to be another key to success promising drug design using lipid emulsion particulate delivery system.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Sanguíneas
/
Proteínas Portadoras
/
Metabolismo de los Lípidos
/
Liposomas
Límite:
Animals
Idioma:
En
Revista:
Int J Pharm
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón