Antigen presentation by the endothelium: a green light for antigen-specific T cell trafficking?
Immunol Lett
; 93(2-3): 109-13, 2004 May 15.
Article
en En
| MEDLINE
| ID: mdl-15158605
ABSTRACT
The functional consequences of recognition of antigen displayed by the endothelium during T cell extravasation in the development of an immune response have been a matter of debate for a long time. Most investigations have focused on the induction of proliferative responses and cytokine production by T cells. In parallel, endothelial cells have been shown to express costimulatory molecules with positive and negative regulatory effects on T cell responses. Recent studies have provided an alternative view of the antigen presenting cell function of endothelial cells, suggesting that cognate recognition of the endothelium by trafficking T cells is a key event in selecting the migration of antigen-specific lymphocytes into the site of inflammation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Movimiento Celular
/
Presentación de Antígeno
/
Endotelio
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Immunol Lett
Año:
2004
Tipo del documento:
Article
País de afiliación:
Reino Unido