[Sterilizing effect of the mutant allele sbr10 (l(1)ts403) in compound with null alleles in Drosophila melanogaster females]. / Sterilizuiushchii éffekt mutantnogo allelia sbr10 (l(1)ts403) v kompaunde s nulevym allelem u samok Drosophila melanogaster.
Genetika
; 40(4): 469-77, 2004 Apr.
Article
en Ru
| MEDLINE
| ID: mdl-15174279
ABSTRACT
In females of Df(1)v-L4/+(0/+) genotype, the presence of the wild-type allele of small bristles (sbr) gene in a single dose has no significant effect on their fecundity, whereas a reduced dose of the temperature-sensitive allele sbr10(l(1)ts403) causes a strong sterilizing effect in females Df(1)v-L4/sbr10 (0/sbr10) at permissive temperature. We studied the contribution to this effects of the following factors resorption of egg chambers, decreased oviposition, offspring death at the embryonic and larval stages, and reduced fecundity in females 0/sbr10. Sterilizing effect of the mutant sbr10 allele proved to be primarily caused by offspring lethality at the embryonic and first-instar larval stages. In 0/+ females, the majority of undeveloped eggs contained embryos that perished at the late developmental stages, whereas in females 0/sbr10, at least 50% of undeveloped egg showed no visible signs of development or the embryo development was arrested at early stages of embryogenesis. The results obtained suggest insufficiency of the temperature-sensitive allele sbr10 in haploid state to ensure the reproductive functions of Drosophila melanogaster females.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_endocrine_disorders
Asunto principal:
Alelos
/
Infertilidad Femenina
/
Mutación
Límite:
Animals
Idioma:
Ru
Revista:
Genetika
Año:
2004
Tipo del documento:
Article