Long-term outcome of pediatric obsessive-compulsive disorder: a meta-analysis and qualitative review of the literature.
Acta Psychiatr Scand
; 110(1): 4-13, 2004 Jul.
Article
en En
| MEDLINE
| ID: mdl-15180774
ABSTRACT
OBJECTIVE:
To review the extant literature on the long-term outcome of child/adolescent-onset obsessive-compulsive disorder (OCD).METHOD:
Medline and Psychlit databases were systematically searched for articles regarding long-term outcomes of child/adolescent-onset OCD. Meta-analysis regression was applied to evaluate predictors and persistence of OCD.RESULTS:
Sixteen study samples (n = 6-132; total = 521 participants) in 22 studies had follow-up periods ranging between 1 and 15.6 years. Pooled mean persistence rates were 41% for full OCD and 60% for full or subthreshold OCD. Earlier age of OCD onset (z = -3.26, P = 0.001), increased OCD duration (z = 2.22, P = 0.027) and in-patient vs. out-patient status (z = 2.94, P = 0.003) predicted greater persistence. Comorbid psychiatric illness and poor initial treatment response were poor prognostic factors. Although psychosocial function was frequently compromised, most studies lacked comprehensive outcome measures.CONCLUSION:
Long-term persistence of pediatric OCD may be lower than believed. Future studies should include broader measures of outcome including symptomatic persistence and functional impairment in multiple domains.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastorno Obsesivo Compulsivo
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Qualitative_research
/
Systematic_reviews
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Acta Psychiatr Scand
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos