Comprehensive pediatric human immunodeficiency virus care and treatment in Constanta, Romania: implementation of a program of highly active antiretroviral therapy in a resource-poor setting.
Pediatr Infect Dis J
; 23(8): 695-700, 2004 Aug.
Article
en En
| MEDLINE
| ID: mdl-15295217
ABSTRACT
BACKGROUND:
Relatively few human immunodeficiency virus (HIV)-infected children worldwide have access to care and treatment. The Romanian-American Children's Center, a collaborative project of a U.S. health care institution and the Romanian government, has established a comprehensive program of highly active antiretroviral therapy for children in Constanta, Romania.OBJECTIVES:
To describe the design and outcomes of a program of pediatric HIV/acquired immunodeficiency syndrome (AIDS) care and treatment in a resource-poor setting.SETTING:
Outpatient center providing comprehensive primary and HIV/AIDS specialty care and treatment to all known HIV-infected children living in Constanta County, Romania.OUTCOMES:
As of August 2003, a total of 452 children were receiving highly active antiretroviral therapy. Therapy has been well-tolerated, with approximately 90% of children continuing to receive treatment after a median duration of follow-up of 67 weeks. Normal weight and height growth velocities have been observed among treated children. Marked decreases have been observed in rates of hospitalization and mortality. The mean change in CD4+ lymphocyte count for 173 children who have both a baseline count and at least 1 follow-up count is +284 cells/microL (P < 0.0001).CONCLUSIONS:
Highly active antiretroviral therapy can be administered safely and effectively to children in a resource-poor setting, with outcomes comparable with those observed in U.S. pediatric antiretroviral clinical trials.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
10_ODS3_salud_sexual_reprodutiva
/
11_ODS3_cobertura_universal
/
2_ODS3
/
4_TD
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Problema de salud:
10_sexually_transmitted_infections
/
11_delivery_arrangements
/
2_enfermedades_transmissibles
/
2_muertes_prevenibles
/
4_aids
/
7_infections
/
7_nutrition
Asunto principal:
Síndrome de Inmunodeficiencia Adquirida
/
Servicios de Salud Comunitaria
/
Terapia Antirretroviral Altamente Activa
/
Atención a la Salud
/
Países en Desarrollo
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Sysrev_observational_studies
Aspecto:
Determinantes_sociais_saude
/
Implementation_research
Límite:
Child
/
Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Pediatr Infect Dis J
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
PEDIATRIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos