Assessment of synthetic peptides of severe acute respiratory syndrome coronavirus recognized by long-lasting immunity.
Tissue Antigens
; 64(5): 600-7, 2004 Nov.
Article
en En
| MEDLINE
| ID: mdl-15496204
ABSTRACT
In order to determine highly immunogenic severe acute respiratory syndrome coronavirus (SARS-CoV) epitope peptides capable of inducing long-lasting immunity, we first screened immunoglobulin-G (IgG) antibodies reactive to 197 different overlapping 15-mers from the SARS-CoV proteins in the sera of three infected patients. Forty-two peptides among them were reactive to the sera from all three patients. Consequently, we tested for the reactivity of these 42 peptides to patients' sera (n = 45) at 6-month post-infection. The significantly higher levels of IgG antibodies specific to three (S791, M207 and N161) of 42 peptides were detectable in the post-infection sera from 23 (51%), 27 (60%) and 19 (42%) of 45 patients, respectively. These three peptides, recognized by their long-lasting immunity, may provide a better understanding of the immunogenicity of SARS-CoV.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Coronavirus Relacionado al Síndrome Respiratorio Agudo Severo
/
Sistema Inmunológico
/
Inmunidad
Límite:
Humans
Idioma:
En
Revista:
Tissue Antigens
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón