Synthesis, physicochemical and pharmacokinetic studies of potential prodrugs of beta-L-2'-deoxycytidine, a selective and specific anti-HBV agent.
Antivir Chem Chemother
; 15(5): 269-79, 2004 Sep.
Article
en En
| MEDLINE
| ID: mdl-15535049
ABSTRACT
beta-L-2'-Deoxycytidine (beta-L-dC) is a potent, selective and specific anti-hepatitis B virus (HBV) agent. To improve its oral bioavailability, several derivatives involving sugar or base acylation, as well N4-derivatization with an N,N-(dimethylamino)methylene function, were synthesized. The physicochemical characteristics (including chemical stabilities, solubilities and distribution coefficient values) and pharmacokinetics of these compounds were determined and compared with those of the parent drug, beta-L-dC.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Profármacos
/
Virus de la Hepatitis B
/
Desoxicitidina
Límite:
Animals
Idioma:
En
Revista:
Antivir Chem Chemother
Asunto de la revista:
QUIMICA
/
TERAPIA POR MEDICAMENTOS
/
VIROLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Francia