Natural killer cells and innate immunity to protozoan pathogens.
Int J Parasitol
; 34(13-14): 1517-28, 2004 Dec.
Article
en En
| MEDLINE
| ID: mdl-15582528
ABSTRACT
Natural killer (NK) cells are lymphoid cells that mediate significant cytotoxic activity and produce high levels of pro-inflammatory cytokines in response to infection. During viral infection, NK cell cytotoxicity and cytokine production is induced principally by monocyte-macrophage- and dendritic cell-derived cytokines but virally encoded ligands for NK cells are also beginning to be described. NK derived interferon-gamma (IFN-gamma) production is also essential for control of several protozoal infections including toxoplasmosis, trypanosomiasis, leishmaniasis and malaria. The activation of NK cells by protozoan pathogens is also believed to be cytokine-mediated although some recent studies suggest that direct recognition of parasites by NK cells also occurs. Both indirect signalling via accessory cell-derived cytokines and direct signalling, presumably through NK receptors, are needed in order for human malaria parasites (Plasmodium falciparum) to optimally stimulate NK activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
/
3_ND
Problema de salud:
2_enfermedades_transmissibles
/
3_malaria
/
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Infecciones por Protozoos
/
Células Asesinas Naturales
Límite:
Humans
Idioma:
En
Revista:
Int J Parasitol
Año:
2004
Tipo del documento:
Article
País de afiliación:
Reino Unido