Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier.
Bioorg Med Chem Lett
; 15(2): 327-30, 2005 Jan 17.
Article
en En
| MEDLINE
| ID: mdl-15603948
ABSTRACT
Schizophyllan having folate-appendages was synthesized from native schizophyllan through NaIO(4)-oxidation and the subsequent reductive amination in aqueous ammonia followed by amido-coupling with folic acid. The resulting folate-appended schizophyllan can form stable complex with poly(dA), show specific affinity toward folate binding protein, and mediate effective antisense activity in cancer cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligonucleótidos Antisentido
/
Sizofirano
/
Ácido Fólico
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Japón