Effect of ranitidine on healing of normal and transfusion-suppressed experimental anastomoses.
Tech Coloproctol
; 8 Suppl 1: s104-7, 2004 Nov.
Article
en En
| MEDLINE
| ID: mdl-15655589
ABSTRACT
BACKGROUND:
Histamine has been shown to participate in immune response. Wound healing is a process of immune system. This experimental study was done to find the effect of histamine2 receptor antagonist ranitidine on the healing process of intestinal anastomosis in rats.METHODS:
Eighty Wistar rats in four groups of 20 each underwent colon resection and anastomosis. They were given 2 ml saline or blood, twice daily 0.4 ml saline or 0.4 ml saline containing 0.7 mg ranitidine. The animals were killed 3 or 7 days postoperatively and the anastomotic strength assessed by bursting pressure.RESULTS:
The ranitidine group developed fewer anastomotic abscesses (p<0.001). Anastomotic strength was significantly reduced either on day 3 or 7 in animals given blood transfusions (p<0.04, p<0.001), whereas in animals given ranitidine this effect was partially reversed.CONCLUSIONS:
These data indicate that ranitidine has no influence in anastomotic bursting pressure, but has a lower incidence of septic complications.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ranitidina
/
Infección de la Herida Quirúrgica
/
Cicatrización de Heridas
/
Transfusión Sanguínea
/
Anastomosis Quirúrgica
/
Colectomía
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Tech Coloproctol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Grecia