DNA topoisomerase I inhibitor, ergosterol peroxide from Penicillium oxalicum.
Planta Med
; 71(1): 77-9, 2005 Jan.
Article
en En
| MEDLINE
| ID: mdl-15678378
ABSTRACT
Recently, we found that the MeOH extract of Penicillium oxalicum showed inhibitory activity towards DNA topoisomerase I. Subsequently, ergosterol peroxide, ergosterol, palmitoleic acid, and linoleic acid were isolated from the cultured mycelia of P. oxalicum. The structural determinations were based on physical and spectral analyses. Biological evaluation revealed that ergosterol peroxide inhibited the relaxation of supercoiled DNA (pBR322) induced by DNA topoisomerase I, and also showed marginal, selective cytotoxic activity against human colon tumor cells [COLO-205 (ED50=8.56 microg/mL].
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Penicillium
/
Inhibidores de la Aromatasa
/
Ergosterol
/
Inhibidores de Topoisomerasa I
/
Fitoterapia
Límite:
Humans
Idioma:
En
Revista:
Planta Med
Año:
2005
Tipo del documento:
Article