[Radical formation by grinding of commercial tablets according to hospital and pharmacy prescription].
Yakugaku Zasshi
; 125(4): 389-96, 2005 Apr.
Article
en Ja
| MEDLINE
| ID: mdl-15802885
ABSTRACT
We examined mechanoradical formation in the grinding process of commercial tablets using electron spin resonance (ESR). Mechanoradicals were detected in all tested samples (23 types of commercial tablets) when the ball-milling of tablets was conducted under anaerobic conditions and some were fairly stable even in air. Thus the grinding may cause changes in the physicochemical properties of ingredients included in commercial tablets. Because high quality is demanded in pharmaceuticals, these results suggest more caution should be taken in the grinding of commercial tablets in hospitals and pharmacies.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prescripciones de Medicamentos
/
Comprimidos
/
Química Farmacéutica
/
Mecánica
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Composición de Medicamentos
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Estabilidad de Medicamentos
/
Radicales Libres
Idioma:
Ja
Revista:
Yakugaku Zasshi
Año:
2005
Tipo del documento:
Article
País de afiliación:
Japón