Transplantation of neonatal porcine islets and sertoli cells into nonimmunosuppressed nonhuman primates.
Transplant Proc
; 37(1): 487-8, 2005.
Article
en En
| MEDLINE
| ID: mdl-15808684
ABSTRACT
A Mexican group reported transplantation of cocultured neonatal porcine islets and Sertoli cells resulting in insulin independence in nonimmunosuppressed type 1 diabetes patients. We have transplanted similar islets alone (naked islets) or cocultured islets with sertoli cells (islet/sertoli cells) into an omental site and other locations of seven nondiabetic, nonimmunosuppressed, nonhuman primates. Porcine endogenous retrovirus was not detected in recipient blood 8 weeks after porcine islet grafts, and porcine C-peptide was detected at a very low level in all animals. Histology examination failed to demonstrate obviously recognizable islets, but in the animals transplanted with islet/Sertoli cells at the omentum site, there were some surviving glucagons, pan-cytokeratin, and inhibin stained cells at 8 weeks.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células de Sertoli
/
Trasplante Heterólogo
/
Trasplante de Islotes Pancreáticos
Límite:
Animals
Idioma:
En
Revista:
Transplant Proc
Año:
2005
Tipo del documento:
Article
País de afiliación:
Singapur