[Effects of Naomaitai capsule on learning and memory and content of Ach in rat model produced by cerebral ischemia-reperfusion].
Zhongguo Zhong Yao Za Zhi
; 30(6): 459-62, 2005 Mar.
Article
en Zh
| MEDLINE
| ID: mdl-15810456
ABSTRACT
OBJECTIVE:
To observe the effects of Naomaitai capsule on the learning and memory abilities and the content of acetylcholine(Ach) in the brain tissue of the model rat.METHOD:
One vascular dementia(VD) model was produced by occlusion of bilateral common carotid arteries in rats with followingsteps:
ischemia 20 minutes-reperfusion 10 minutes-ischemia 20 minutes. The learning and memory abilities were tested by water maze. The other VD model was formed by 4-vessel occlusion-reperfusion injury in rats. The time of right reflect recovery and the content of Ach in the brain tissue were determined.RESULT:
Naomaitai capsule can significantly improve the learning and memory abilities of the dementia rats( P < 0.05, P < 0.01), increase the content of Ach (P < 0.05, P < 0.01) and reduce the time of right reflect recovery(P < 0.01).CONCLUSION:
Naomaitai capsule can improve the learning and memory abilities by increasing the content of Ach of the VD rats.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
/
Daño por Reperfusión
/
Acetilcolina
/
Aprendizaje
/
Memoria
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Asunto de la revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Año:
2005
Tipo del documento:
Article
País de afiliación:
China