[Protective effect of ligusticum chuanxiong phthalides on focai cerebral ischemia in rats and its related mechanism of action].
Zhongguo Zhong Yao Za Zhi
; 30(6): 466-8, 2005 Mar.
Article
en Zh
| MEDLINE
| ID: mdl-15810458
ABSTRACT
OBJECTIVE:
To study the protective effect of ligusticum chuanxiong phthalides on cerebral ischemia in rats and its related mechanism of action.METHOD:
Middle cerebral artery occlusion (MCAO) model, thrombosis formation, platelet aggregation and hemorrheological parameters were measured to evaluate the protective effect of ligusticum chuanxiong phthalides.RESULT:
Ligusticum chuanxiong phthalides could markedly decrease the infarct size and behavior deficits score, inhibit the thrombus formation and platelet aggregation, ameliorate hemorrheological parameters with a dose-dependent manner in rats.CONCLUSION:
Ligusticum chuanxiong phthalides has protective effects on focal cerebral ischemia in rats, and its mechanism may be relevant to its inhibition of platelet-dependent thrombosis and amelioration of hemorrheological parameters.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Benzofuranos
/
Isquemia Encefálica
/
Fármacos Neuroprotectores
/
Trombosis de la Vena
/
Ligusticum
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Asunto de la revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Año:
2005
Tipo del documento:
Article
País de afiliación:
China