Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis.
Crit Care Med
; 33(4): 792-6, 2005 Apr.
Article
en En
| MEDLINE
| ID: mdl-15818107
ABSTRACT
OBJECTIVE:
To describe the course of plasma sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin (PCT), and C-reactive protein (CRP) concentrations during sepsis and their clinical informative value in predicting outcome.DESIGN:
Prospective, noninterventional study.SETTING:
Medical adult intensive care unit at a university hospital in France. PATIENTS Sixty-three critically ill patients with sepsis, severe sepsis, or septic shock.INTERVENTIONS:
None. MEASUREMENTS AND MAINRESULTS:
Soluble TREM-1 concentrations were significantly lower at admission in nonsurvivors (n = 21) than in survivors (n = 42) (94 [30-258] vs. 154 [52-435] pg/mL, p = .02), whereas PCT levels were higher among nonsurvivors (19.2 [0.3-179] vs. 2.4 (0-254) pg/mL, p = .001). CRP levels did not differ between the two groups of patients. Plasma PCT and CRP decreased during the 14-day period of study in both survivors and nonsurvivors. Conversely, sTREM-1 plasma concentrations remained stable or even increased in nonsurviving patients and decreased in survivors. An elevated baseline sTREM-1 level was found to be an independent protective factor with an odds of dying of 0.1 (95% confidence interval, 0.1-0.8).CONCLUSION:
A progressive decline of plasma sTREM-1 concentration indicates a favorable clinical evolution during the recovery phase of sepsis. In addition, baseline sTREM-1 level may prove useful in predicting outcome of septic patients.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
4_TD
Problema de salud:
4_sepsis
Asunto principal:
Precursores de Proteínas
/
Proteína C-Reactiva
/
Calcitonina
/
Glicoproteínas de Membrana
/
Receptores Inmunológicos
/
Sepsis
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Crit Care Med
Año:
2005
Tipo del documento:
Article
País de afiliación:
Francia