Risedronate in the treatment of Murine Chagas' disease.
Parasitol Res
; 96(3): 184-7, 2005 Jun.
Article
en En
| MEDLINE
| ID: mdl-15844009
ABSTRACT
Risedronate, a bisphosphonate, was used to treat CD-1 mice infected with the Brazil strain of Trypanosoma cruzi. When given by subcutaneous injection 3 times/week, there was a significant reduction in mortality, however, the myocardial pathology and right ventricular dilation was unchanged in these mice compared to control animals. In C57BL/6 mice infected with the Tulahuen strain, there was no change in mortality in response to risedronate treatment. These data suggest that this class of compounds has activity against T. cruzi in vivo and illustrate the utility of imaging and pathologic studies as adjuncts in the evaluation of therapeutic compounds as treatments for experimental Chagas' disease. In addition, it underscores the need to use different strains of T. cruzi.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
/
3_ND
/
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
2_enfermedades_transmissibles
/
3_zoonosis
/
6_cardiovascular_diseases
Asunto principal:
Trypanosoma cruzi
/
Cardiomiopatía Chagásica
/
Ácido Etidrónico
/
Enfermedad de Chagas
Límite:
Animals
Idioma:
En
Revista:
Parasitol Res
Asunto de la revista:
PARASITOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos