Effect of interferon on incidence of hepatocellular carcinoma in patients with chronic hepatitis C.
Hepatogastroenterology
; 52(64): 1154-8, 2005.
Article
en En
| MEDLINE
| ID: mdl-16001651
ABSTRACT
BACKGROUND/AIMS:
The aim of this study was to evaluate whether IFN prevents the development of HCC in patients with chronic hepatitis C.METHODOLOGY:
103 patients with chronic hepatitis C received IFN and 30 control patients were enrolled in this study.RESULTS:
In 33 patients (32.0%) who received IFN, alanine aminotransferase (ALT) decreased to normal range and HCV RNA became negative (complete response CR). In 7 patients (6.7%), ALT decreased to less than 50 IU/L or stayed within the normal range, but HCV RNA remained positive (biochemical response BR). In 63 patients (61.1%) and 30 control patients, ALT did not change and HCV RNA remained positive (no response NR). HCC developed in 5 (4.9%) of the 103 patients who received IFN and 7 (23.3%) of the control patients (p<0.01). In 5 patients who developed HCC, the response to IFN was NR and no HCC developed in patients with CR or BR. In addition, 5-year cumulative rate of development of HCC in 63 IFN NR patients and in control was 7.9% and 23.3% (p<0.05).CONCLUSIONS:
IFN decreased the development of HCC in not only patients with CR or BR but also patients with NR.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_enfermedades_transmissibles
Asunto principal:
Antivirales
/
Interferones
/
Carcinoma Hepatocelular
/
Hepatitis C Crónica
/
Neoplasias Hepáticas
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Hepatogastroenterology
Año:
2005
Tipo del documento:
Article
País de afiliación:
Japón