New pharmacological approaches to therapy of NIDDM.
Diabetes Care
; 15(6): 792-805, 1992 Jun.
Article
en En
| MEDLINE
| ID: mdl-1600838
ABSTRACT
Currently available pharmacological agents have not been completely successful in restoring euglycemia in the non-insulin-dependent diabetes mellitus (NIDDM) patient. Several new approaches to the therapy of NIDDM have been formulated in recent years and are in various stages of laboratory or pharmaceutical development. Several of these agents are discussed in this article under categories relating to their mechanisms of lowering blood glucose 1) inhibition of the release or action of counterregulatory hormones; 2) inhibition of postprandial glucose rise; 3) sensitization of tissues to insulin's actions; and 4) inhibition of gluconeogenesis, including inhibition of the long-chain acyl-CoA-carnitine acyltransferase I, the long-chain acylcarnitine translocase, and pyruvate carboxylase.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus Tipo 2
/
Inhibidores Enzimáticos
/
Hipoglucemiantes
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Diabetes Care
Año:
1992
Tipo del documento:
Article