ANCA: serology in Wegener's granulomatosis.
Indian J Med Sci
; 59(7): 292-300, 2005 Jul.
Article
en En
| MEDLINE
| ID: mdl-16062016
ABSTRACT
BACKGROUND AND OBJECTIVES:
Wegener's granulomatosis (WG) is being increasingly diagnosed in India, which exists in two forms, the 'limited Wegener's granulomatosis' (LWG) having upper respiratory tract (URT) and lower respiratory tract (LRT) involvement and the 'classical Wegener's granulomatosis' (CWG), with the triad of URT, LRT involvement along with kidney involvement. Cytoplasmic ANCA (C-ANCA) or anti-Proteinase3 (anti-PR3), which is highly diagnostic for WG, rarely perinuclear ANCA (P-ANCA) may exist.AIMS:
To detect anti-neutrophil cytoplasmic antibodies (ANCA) and correlate it with serological, hematological parameters, and the Birmingham Vasculitis Activity Score (BVAS). SETTINGS ANDDESIGN:
Twenty-three clinically and histopathologically proven WG (16 CWG, 7 LWG) were studied. MATERIAL ANDMETHODS:
C-ANCA and P-ANCA patterns were identified by immunofluorescence and specificities were confirmed by 'alpha granule' enzyme linked immunosorbent assay (ELISA), anti-PR3, anti-MPO (myeloperoxidase) and anti-Lactoferrin (anti-LF) by ELISA.RESULTS:
LRT involvement was seen in 91.3%, URT in 78.3%, and renal manifestations in 69.6% cases. The BVAS in CWG was significantly higher than BVAS in the LWG. Decreased hemoglobin, increased WBC counts, ESR, CRP and Creatinine were seen in CWG as compared to LWG. The C-ANCA was present in 65.2% patients and P-ANCA in 13% cases. Anti-PR3 was seen in 69.6% patients and anti-LF in 17.4% cases. Severity of disease and ANCA was higher in CWG than in LWG.CONCLUSIONS:
Vasculitis syndromes are known to overlap and many go undetected; therefore ANCA testing, along with the clinical and histopathological observations may be helpful in early detection and management of WG cases.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Granulomatosis con Poliangitis
/
Anticuerpos Anticitoplasma de Neutrófilos
Tipo de estudio:
Prognostic_studies
/
Screening_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Indian J Med Sci
Año:
2005
Tipo del documento:
Article
País de afiliación:
India