Neurogenesis and neuronal communication on micropatterned neurochips.
Biotechnol Bioeng
; 92(3): 336-45, 2005 Nov 05.
Article
en En
| MEDLINE
| ID: mdl-16094670
ABSTRACT
Neural networks are formed by accurate connectivity of neurons and glial cells in the brain. These networks employ a three-dimensional bio-surface that both assigns precise coordinates to cells during development and facilitates their connectivity and functionality throughout life. Using specific topographic and chemical features, we have taken steps towards the development of poly(dimethylsiloxane; PDMS) neurochips that can be used to generate and study synthetic neural networks. These neurochips have micropatterned structures that permit adequate cell positioning and support cell survival. Within days of plating, cells differentiate into neurons displaying excitability and communication, as evidenced by intracellular calcium oscillations and action potentials. The structural and functional capacities of such simple neural networks open up new opportunities to study synaptic communication and plasticity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Madre
/
Potenciales de Acción
/
Transmisión Sináptica
/
Técnicas de Cultivo de Célula
/
Dimetilpolisiloxanos
/
Red Nerviosa
/
Neuronas
/
Nylons
Límite:
Animals
Idioma:
En
Revista:
Biotechnol Bioeng
Año:
2005
Tipo del documento:
Article
País de afiliación:
Canadá