Fibroblast growth stimulation by extracts and compounds of Onosma argentatum roots.
J Ethnopharmacol
; 104(1-2): 100-3, 2006 Mar 08.
Article
en En
| MEDLINE
| ID: mdl-16226418
ABSTRACT
The roots of Onosma argentatum are used traditionally in Turkey for wound healing and burns. The n-hexane-dichloromethane extract of the roots, and four shikonin derivatives (deoxyshikonin, acetyl shikonin, 3-hydroxy-isovaleryl shikonin and 5,8-O-dimethyl acetyl shikonin) isolated from the n-hexane-dichloromethane extract were investigated for their ability to stimulate the growth of human amnion fibroblasts. A range of concentrations was studied and the extract found to stimulate the growth of human amnion fibroblasts in vitro at 0.1 microg/mL whilst 5,8-O-dimethyl acetyl shikonin had the same effect at 0.05-5 microg/mL, although cytotoxicity was observed at 50 microg/mL for all samples. The extract and all the other isolated compounds showed cytotoxicity at 10 microg/mL with the extract and 3-hydroxy-isovaleryl shikonin showing cytotoxicity at 5 microg/mL. It is suggested that any wound healing effect of the roots of Onosma argentatum might be partly due to an additive effect of the shikonin derivatives present.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sustancias de Crecimiento
/
Boraginaceae
/
Proliferación Celular
/
Fibroblastos
Límite:
Humans
Idioma:
En
Revista:
J Ethnopharmacol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Turquía