The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
Bioorg Med Chem Lett
; 16(1): 142-5, 2006 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-16236511
ABSTRACT
For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n-butylmansonone F showed fourfold higher antibacterial activities compared to that of vancomycin.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinonas
/
Sesquiterpenos
/
Naftoquinonas
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2006
Tipo del documento:
Article