Skin biopsies for the measurement of clinical pharmacodynamic biomarkers.
Curr Opin Biotechnol
; 16(6): 687-90, 2005 Dec.
Article
en En
| MEDLINE
| ID: mdl-16257524
ABSTRACT
The integration of biomarkers reporting on drug pharmacodynamics or on a disease state is becoming necessary in the cost-effective design of clinical trials. Transcriptional changes in skin measured using whole-genome arrays have been useful in assessing the disease state in dermatology. Not only are skin biopsies well-tolerated and easy to obtain, but they sample a system in which many complex signaling and developmental networks are active and in which a wide variety of drug targets may be expected to play a role, either directly or indirectly. Recent advances have led to the use of transcriptional profiling of skin for making pharmacodynamic measurements in clinical trials, even for non-dermatological conditions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Farmacocinética
/
Preparaciones Farmacéuticas
/
Regulación de la Expresión Génica
/
Perfilación de la Expresión Génica
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Biotechnol
Asunto de la revista:
BIOTECNOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos