Design, synthesis and antiproliferative activity of some new azapyranoxanthenone aminoderivatives.
Eur J Med Chem
; 41(1): 71-9, 2006 Jan.
Article
en En
| MEDLINE
| ID: mdl-16300857
ABSTRACT
Some novel aminosubstituted azapyranoxanthenones, bearing structural similarity to the acridone alkaloid acronycine, have been designed and synthesized. Their in vitro cytotoxicities against the murine L1210 leukemia and the human solid tumor HT-29 cell lines have been investigated. Their eventual selective effect on a phase of the cell cycle was evaluated, using HT-29 cells. A number of the new derivatives exhibited interesting cytotoxic activity against the human solid tumor cell line.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Xantenos
/
Acronina
/
Proliferación Celular
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Eur J Med Chem
Año:
2006
Tipo del documento:
Article
País de afiliación:
Grecia