The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure.
Genetics
; 172(2): 1369-72, 2006 Feb.
Article
en En
| MEDLINE
| ID: mdl-16322523
ABSTRACT
We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II, leading to transcription of critical genes that sustain growth.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Saccharomyces cerevisiae
/
Regulación Fúngica de la Expresión Génica
/
Sirolimus
/
Proteínas de Saccharomyces cerevisiae
/
Antifúngicos
Idioma:
En
Revista:
Genetics
Año:
2006
Tipo del documento:
Article
País de afiliación:
Canadá