Oocytes in the empty follicle: a controversial syndrome.
Fertil Steril
; 84(6): 1643-8, 2005 Dec.
Article
en En
| MEDLINE
| ID: mdl-16359958
ABSTRACT
OBJECTIVE:
To assess the prevalence and etiology of the empty follicle syndrome (EFS).DESIGN:
Observational longitudinal study.SETTING:
Tertiary fertility centers. PATIENT(S) All patients beginning in vitro fertilization (IVF) treatment from December 2002 to November 2004 were included. Couples undergoing IVF with donor oocytes or participating in an experimental IVF study were excluded from analysis. INTERVENTION(S) Identification of EFS cycles. Comparing ovarian hyperstimulation strategy, follicle count, and timing of human chorionic gonadotropin (hCG) for final oocyte maturation of the EFS cycles with normal IVF cycles. MAIN OUTCOME MEASURE(S) Number of follicles punctured, number of oocytes recovered, previous and future IVF attempts, and serum hormone levels. RESULT(S) Twenty-five of a total of 1,849 patients were identified with an EFS cycle. Reasons for occurrence of EFS cycles were mistiming of hCG for final oocyte maturation, premature ovulation, and poor ovarian response. None of the affected patients had experienced EFS cycles in earlier IVF attempts nor were there any recurrence in subsequent treatments. CONCLUSION(S) Accurate timing of induction of final oocyte maturation, properly scheduled ovarian hyperstimulation, instruction of patients and doctors, and full workup for IVF are essential for the successful recovery of oocytes. Occurrence of EFS in IVF can normally be attributed to a failure of at least one of these factors and probably rarely or never occurs otherwise.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oocitos
/
Enfermedades del Ovario
/
Folículo Ovárico
/
Infertilidad Femenina
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Fertil Steril
Año:
2005
Tipo del documento:
Article
País de afiliación:
Países Bajos